Fig. 3

Lifestyle, demographic factors, and blood cell count influencing mtDNA seasonal patterns. The size and color of the circles indicate the effect on the seasonal pattern of mitochondrial abundance. Blue circles indicate that the marker reduced the respective pattern and red increased it. Amplitude designates the effect on the difference between the minimum and maximum values in the seasonal pattern and is given as the fraction of the total amplitude (which is 0.091 standard deviations). Displacement is the vertical shift in the mean value across all seasons (i.e., the marginal effect in the regression model) and is given in % of a standard deviation. The change in the time until the peak in the wave is reached is described by the acrophase and is given in a fraction of a month. A: Association of lifestyle factors as well as frailty on seasonal patterns. B: Whole blood cell counts associated with seasonal patterns